Thursday, February 14, 2013

Inflammation and Heart Disease

Atherosclerosis is the most common pathological process leading to cardiovascular (heart and blood vessel) disease with most atherosclerotic lesion development (plaque build up) confined to regions of arterial curvature (bends) and branch points, which are exposed to disturbed blood flow.(1)

Although the atherosclerotic process is not fully understood, atherosclerosis is initiated by an inflammatory process in the blood vessel wall. This inflammatory process also accounts for the high incidence of plaque build up at bend points in the blood vessels which will suffer the most "rubbing" by particles in your bloodstream. This can be attributed to the fact that the body's natural response to inflammation or irritation is to add a protective layer to the inflamed and irritated area. This protective layer for the arteries would be the plaquing that develops. Continued rubbing and inflammation is accompanied by ongoing plaque build up and the arteries narrow and become less flexible decreasing the blood supply to all the areas of the body served by these narrowed and hardened arteries.(2) This results in the increased risk of stroke and heart attack.

It is now clear that inflammation plays a key role in atherogenesis. As a matter of historical fact, signs of inflammation and atherosclerotic plaques have been observed for centuries and also constituted the basis for a fierce controversy in the 19th century between the prominent Austrian pathologist Carl von Rokitansky and his German counterpart, Rudolf Virchow. While Rokitansky attributed a secondary role to these inflammatory arterial changes, Virchow considered them to be of primary importance. Modern researchers had the unique opportunity to address this controversy by investigating atherosclerotic specimens from autopsies performed by Carl von Rokitansky almost 200 years ago. Twelve atherosclerotic arteries originally collected between the years 1827 to 1885 were selected from the Collectio Rokitansky of the Federal Museum of Pathological Anatomy, Vienna Medical University. Using modern scientific techniques, it was shown that inflammation is an initiating factor in atherogenesis proving Virchow's point.(3)

As Virchow's research demonstrated in the 1800's and current research has confirmed today, atherosclerosis, a leading cause of heart disease in the world, is initiated by an ongoing inflammatory response. Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the majority of the complications in heart disease.
In addition, low-grade chronic inflammation, as indicated by the levels of the inflammatory markers in the blood, defines a person's risk of atherosclerotic complications. Virchow was right when assigning inflammation a primary role in the atherosclerotic disease process and the new insights into inflammation in atherosclerosis not only increase our understanding of this disease, but also provide a practical application in the targeting of therapy for this scourge of growing worldwide importance.(4)

Current research has also shown that diet plays a significant role in the inflammatory process in the body. A poor diet loaded with processed and packaged foods will increase inflammation while a healthy diet heavy in unprocessed fresh foods decreases the risk of inflammation and can actually help heal damage already done. The four simple recommendations that follow can help decrease the inflammation and start the healing process today.

Fish:
Polyunsaturated fats – especially omega-3 fatty acids – help suppress cytokines and other inflammatory chemicals.
These good fats also help decrease LDL "bad" cholesterol and triglyceride levels when used to replace saturated and trans fats in the diet. High levels of LDL cholesterol and triglycerides (fats in the blood) promote inflammation, which is thought to play a critical role in heart disease. That's important for people with RA, who have a significantly higher risk of heart disease.
All fish have some omega-3s. But salmon, herring, sardines, and anchovies are chock full of them. Salmon provides the most, with up to 2 grams of omega-3 fatty acids per 3-ounce serving. Go lightly with the heat; overcooking can destroy more than half of the omega-3s. Bake or grill fish instead of frying it to preserve healthful fat.
The American Heart Association recommends eating fish twice a week. Fish high in omega-3s are powerful anti-inflammatory foods that offer a multitude of health benefits. Don't like fish? Other foods rich in omega-3 fatty acids include walnuts

Colorful Produce:
Nutritionists often advise people to add color to their diet. Why? The substances that give fruits and vegetables their color – flavonoids and carotenoids – are also potent antioxidants. Antioxidants are an important component of an inflammation-fighting diet. Vitamin C is another antioxidant found in many fruits and vegetables.
Fruits and veggies high in these antioxidants include blueberries, blackberries, squash, sweet potatoes, carrots, tomatoes, peppers, oranges, broccoli, and melons.
Choosing colorful foods – with red, orange, yellow, blue, green, and purple hues – will ensure you eat a variety of fruits and vegetables and help you have a balanced diet.

Whole Grains:
Whole-wheat pasta and breads -- hallmarks of the Mediterranean Diet -- also contain selenium, an inflammation-fighting antioxidant. Some people with rheumatoid arthritis have lower levels of selenium levels in their blood.
Another advantage of eating whole grains instead of refined carbohydrates – such as white bread and white rice – is that whole grains may help you manage your weight better. Staying at a normal weight – or losing weight if you need to – will take pressure off painful joints.

Olive Oil:
Studies show that a compound in olive oil stops the production of the chemicals that induce inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen work to lower inflammation by reducing the production of these same chemicals. Another study found that olive oil was similar to ibuprofen at reducing inflammation.
When it comes to fighting inflammation, opt for extra-virgin olive oil. Extra-virgin olive oil comes from the first pressing of the olive and contains the highest content of health-promoting nutrients.(5)

In summary a pro-inflammatory diet much like the typical "modern" or "western" diet will increase the risk of inflammation and therefore heart disease and an anti-inflammatory diet full of vegetables, fruits, whole grains, and vegetable oils decrease the inflammatory process and heart disease.

1) http://ndt.oxfordjournals.org/content/22/7/1823.
2) http://en.wikipedia.org/wiki/Atherosclerosis
3) http://cel.webofknowledge.com/InboundService.do?SID=1CLhJobB7FEB3JA8ijE&product=CEL&UT=000238671000011&SrcApp=Highwire&Init=Yes&action=retrieve&Func=Frame&customersID=Highwire&SrcAuth=Highwire&IsProductCode=Yes&mode=FullRecord
4) http://circ.ahajournals.org/content/105/9/1135.full
5) "http://www.webmd.com/rheumatoid-arthritis/biologics-10/ra-diet" http://www.webmd.com/rheumatoid-arthritis/biologics-10/ra-diet

This article is also published at www.Balkanchronicles.com.

My most recent book "God's Health Care Initiative" is available on Kindle ebooks. I maintain an active health care practice in Nutrition and Herbal Therapies, Chiropractic and Exercise. Feel free to contact me for consultations through this blog or on Facebook at God's Health Care Initiative.

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